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A total of 1066 thoracic aortas from cases of advanced aortic valve diseases were used for a study of aortic atherosclerosis. Atherosclerosis was found in 42% of aortas from cases of isolated aortic regurgitation (AR), but in only 2% of those from cases of isolated aortic stenosis (AS) and in none of aortas from cases of mixed aortic stenosis and regurgitation (MS). The incidence of atherosclerosis was found to be significantly higher in AS and AR (2 and 4%) than in MS (0%), and increased with the degree of the aortic regurgitation. The aortic wall thickness was greater in AS (1.1 cm) than in AR (0.7 cm) and MS (0.6 cm), and
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